Thyroid Overconversion is directly linked to Polycystic Ovarian Syndrome (PCOS) and Insulin Resistance (pre-diabetes).
Androgens includes any of the 19-carbon steroids synthesized by the adrenal cortex, the outer portion of the adrenal gland, that function as weak steroids or steroid precursors, stimulate or control the development and maintenance of male characteristics including Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), and Androstenedione or Etiocholanolone that causes fever, immunostimulation, and leukocytosis (increased White Blood Cell (WBC) numbers and activity, and bone marrow production of immune messengers and cells to stimulate the immune system.
PCOS and Insulin Resistance mimic Thyroid Symptoms
insulin resistance, which also causes a shift in androgens (male type hormones) in women, diabetes and obesity, is strongly correlated with PCOS. PCOS and insulin resistance are the great mimickers of thyroid disorders.
What are the symptoms of polycystic ovary syndrome (PCOS)?
Not all women with PCOS share the same symptoms. These are some of the symptoms of PCOS:
- Weight gain or obesity, usually carrying extra weight around the waist
- Male-pattern baldness or thinning hair
- Patches of thickened and dark brown or black skin on the neck, arms, breasts, or thighs
- Skin tags, or tiny excess flaps of skin in the armpits or neck area
- Infrequent menstrual periods, no menstrual periods, and/or irregular bleeding
- Infertility (not able to get pregnant) because of not ovulating
- Increased hair growth on the face, chest, stomach, back, thumbs, or toes-a condition called hirsutism
- Ovarian cysts
- Acne, oily skin, or dandruff
- Insulin resistance (Pre-Diabetes) or type 2 diabetes
- High cholesterol
- High blood pressure
- Pelvic pain
- Anxiety or depression due to appearance and/or infertility
- Sleep apnea-excessive snoring and times when breathing stops while asleep
How many of the symptoms listed above are “Thyroid” Symptoms? Are you starting to understand that the thyroid is not the only organ in the body that can cause these symptoms? Would you like someone who looks at the whole body and not just the thyroid. It really doesn’t matter what causes you to feel the way you do. It matters how they find it and fix it.
Etiocholanolone Surge – Hot Flashes
Etiocholanolone is produced from androstenedione. Excessive DHEA supplementation may be the cause of high etiocholanolone levels. Classified a ketosteroid, Etiocholanolone has no androgenic activity.
If lab test reports DHEA, androstenedione and testosterone levels are low with signs and a person has symptoms of bacterial overgrowth, high pro-inflammatory cytokines IL-1, IL-6 levels, Etiocholanolone may be causing symptoms of inflammation (hot flashes), fever, leukocytosis, increased serum C-reactive protein, low iron (hypoferremia), increased IL-1 lymphocyte activation and increased white blood cell activity.
In some cases Etiocholanolone has been known to decrease cortisol in short bursts because it has a higher affinity for the parts of the adrenals (Zona Glomerulosa & Zona Reticularis) which effect mineralocorticoids, salt and water content of your blood, and Androgens (testosterone).
Increased etiocholanolone causes a rapid fall in serum iron and a rise in serum ferritin. Leading to the diagnosis of Iron Deficiency Anemia. Overlooking the real issue of Anemia of Chronic Inflammation, which is not an iron deficiency problem but is the result of iron sequestration as the body attempts to restrict iron access to bacteria using as a part of their normal reproduction. Thereby, reducing the bacterial numbers and the consequential inflammation they would cause.
Androgenic Overexposure Over Converts T4
Androgenic overexposure tends to up-regulate the enzyme responsible for converting T4 into T3. Chronic elevation of T3 has been found clinically to cause thyroid resistance syndromes; therefore, although the elevation of T3 may seem beneficial, the patient present with symptoms of low thyroid due to resistance from increased T3 production.
This pattern is usually found in women suffering from the androgenic drives caused by insulin resistance in polycystic ovary syndrome (PCOS). Men with this pattern will have the signs and symptoms associated with Andropause but will not be told their elevated blood sugar, cholesterol/triglycerides and elevated blood pressure are linked to this pattern. Chronic elevations of insulin then to up-regulate then enzymes in the ovaries/testicles and promote androgenic drives. The management of this thyroid disorder is to manage the insulin resistance.
If a person is type II diabetic and on insulin replacement, this pattern is possible. With this pattern attempts to decrease the demand for insulin, diet, nutritional supplementation and exercise is crucial.
Sometimes, elevations of the androgens causing this pattern are not from elevated insulin, but rather from increased intake of exogenous bio-identical hormones or androgen precursors. In these cases, support of phase I and II liver detoxification is recommended, if hepatic portal hypertension is not a problem. Hepatic Portal Hypertension will cause the liver to be bypassed.
Read More about the Six Patterns of Low Thyroid Function
Click on the links below:
- The only time to use Iodine or Selenium to restore normal Thyroid Function.
- Primary Hypothyroidism is a thyroid treatable condition.
- Suppressed Hypothalamus-Pituitary function from exogenous Melatonin, Somatostatin, Impaired Vasomotor control leading to Ischemia of the Blood-Brain-Barrier, Hypothalamus, Hippocampus and Pituitary.
- Hippocampus, hypothalamic and pituitary suppression of Thyroid Stimulating Hormone (TSH) production results in Low Thyroid Symptoms.
- Cortisol imbalances causing downstream production of thyroid suppressing corticosteroid hormones measured by the Genova Complete Hormone Panel.
- Thyroid hormone suppressing corticosteroid hormones mimic Low Thyroid Symptoms.
- Thyroid Overconversion is directly linked to Insulin Resistance and Polycystic Ovarian Syndrome (PCOS).
- Insulin resistance and PCOS symptoms mimic Low Thyroid Symptoms.
- Thyroid Hormone Binding Elevation is a pattern associated with elevation of Multiple Estrogens caused by impaired clearance due to Hepatic Portal Hypertension, and/or bacterial toxins preventing clearance of hormones from the body. Another factor to consider is alteration to the Hypothalamus-Pituitary-Gonad (HPG) Axis.
- Elevation in Estrogen mimic Low Thyroid Symptoms.
- Thyroid Resistance is caused by cellular inflammation occurring throughout the body. An possibility is failure to adequately monitor Thyroid Hormone Medications.
- Cellular Inflammation and improper Thyroid Hormone Medication dosage mimics Low Thyroid Symptoms.