Thyroid Binding Hormone Elevations
This pattern is common from elevations of estrogens. It is usually from exogenous estrogen exposure such as oral contraceptives, hormone replacement therapy or failure to clear estrogens due to Hepatic Portal Hypertension and putrefaction dysbiosis. Elevations of estrogen increase thyroid hormone binding and therefore the free T3, T4 and T3 Uptake are reduced.
TSH production is reduced by somatostatin (SRIH), rising levels of glucocorticoids (cortosol) and sex hormones (estrogen and testosterone), and excessively high blood iodine concentration.
The Symptoms of Estrogen Dominance in Women
- Mood swings
- Night sweats
- Vaginal dryness
- Insomnia & restlessness
- Hot flushes
- Irregular/absent periods
- Menstrual cramps (dysmenorrhea)
- Heavy periods
- Tender breasts
- Dry skin
- Water retention and bloating
- Lack of libido (sex drive)
- Fibryocystic breasts
- Uterine fibroids
- Polycystic ovary syndrome
- Breast cancer
Symptoms of excessive estrogen in Men include:
- Prostate problems
- Reduced sex drive
- Weight gain
- Testicular shrinkage
- Man boobs – The development of breasts (gynecomastia)
Putrefactive Dysbiosis which results from failure or reduced production of stomach acid, which is necessary to stimulate the release of juices and enzymes the pancreas and bile from the gallbladder. Without digestive chemistry, food (even the best organic or paleo diets) will putrefy leading to gas and ammonia production.
This reduction of chemical digestion of what ever diet you are eating (even the “healthy” diets) results in increased concentrations of Lactobacillus acidophilus sp. (ones that love acid) which release increased amounts of bacterial enzymes: urease and beta-glucuronidase activity. These enzymes may then convert bile acids to tumor promoters and prevent estrogens from being cleared out of the body, raising blood estrogen level.
Most office test only the “Big 5” – Cortisol, DHEA, Progesterone, Testosterone and Estrogen. They have that perception that hormones stay as whatever hormone they are produced as, e.g. Progesterone stays as progesterone. When pro-g-esterrone is pre- or before being converted into estrogen. Estrogen is typically Estraiol (E2) which is the predominant hormone preparing a woman’s body for the possibility of pregnancy. Then E2 is generically referred to as representative of “Estrogen” levels.
Even worse are the memes like”your body will know what to do with the excess” or “your body will get rid of excess hormone” Well technically, they are correct. Your body will know what to do with the hormones or get rid of it by converting hormones to different downstream hormones. Then new names are given to your condition like “Estrogen Dominance”.
At Wellness Alternatives, Complete Hormone Tests are done measuring all 41 hormones. Recognizing that hormones convert into downstream hormones and clearing hormones out of the system may be a problem when bacteria start hacking into the NEI Supersystem, changing blood flow and feedback regulation or during hepatic portal hypertension where blood pools in the veins of the abdomen (varicose veins, internal or external hemorrhoids, blood in the stool). Testing all 41 hormones allows us to see where the hormones are going and how they are affecting your thyroid.
T3 and T4 regulation
The production of thyroxine (T4) and triiodothyronine (T3) is regulated by thyroid-stimulating hormone (TSH), released by the anterior pituitary. The thyroid and thyrotropes (cells in the anterior pituitary) form a negative feedback loop: TSH production is suppressed when the T4 levels are high, and vice versa. The TSH production itself is modulated by thyrotropin-releasing hormone (TRH), which is produced by the hypothalamus and secreted at an increased rate in situations such as cold (in which an accelerated metabolism would generate more heat). TSH production is blunted by somatostatin (SRIH), rising levels of glucocorticoids (cortosol) and sex hormones (estrogen and testosterone), and excessively high blood iodide concentration.
Somatostatin is classified as an inhibitory hormone, whose actions are spread to different parts of the body.
Almost all factors related to the ingestion of food will stimulate somatostatin secretion. These include:
- Increased blood glucose
- Increased amino acids
- Increased fatty acids
- Increased concentrations of several of the gastrointestinal hormone released from the upper gastrointestinal tract in response to food intake.
In the anterior pituitary gland, the effects of somatostatin are:
- Inhibit the release of growth hormone (GH) (thus opposing the effects of Growth
Hormone-Releasing Hormone (GHRH))
- Inhibit the release of thyroid-stimulating hormone (TSH)
- It is induced by low pH.
- Secreted by “D” cells and alpha cells in Islet of Langerhans.
- Inhibit adenylyl cyclase in parietal cells.
- Suppress the release of gastrointestinal hormones
- Cholecystokinin (CCK)
- Vasoactive intestinal peptide (VIP)
- Gastric inhibitory polypeptide (GIP)
- Lowers the rate of gastric emptying, and reduces smooth muscle contractions and blood flow within the intestine
- Suppress the release of pancreatic hormones
- Inhibit the release of insulin
- Inhibit the release of glucagon
- Suppress the exocrine secretory action of pancreas.
The principal role of somatostatin is to extend the period of time over which the food stays in the upper digestive tract allowing nutrients longer contact with the intestinal lining to be absorbed into the portal blood system.
Read More about the Six Patterns of Low Thyroid Function
Click on the links below:
- The only time to use Iodine or Selenium to restore normal Thyroid Function.
- Primary Hypothyroidism is a thyroid treatable condition.
- Suppressed Hypothalamus-Pituitary function from exogenous Melatonin, Somatostatin, Impaired Vasomotor control leading to Ischemia of the Blood-Brain-Barrier, Hypothalamus, Hippocampus and Pituitary.
- Hippocampus, hypothalamic and pituitary suppression of Thyroid Stimulating Hormone (TSH) production results in Low Thyroid Symptoms.
- Cortisol imbalances causing downstream production of thyroid suppressing corticosteroid hormones measured by the Genova Complete Hormone Panel.
- Thyroid hormone suppressing corticosteroid hormones mimic Low Thyroid Symptoms.
- Thyroid Overconversion is directly linked to Insulin Resistance and Polycystic Ovarian Syndrome (PCOS).
- Insulin resistance and PCOS symptoms mimic Low Thyroid Symptoms.
- Thyroid Hormone Binding Elevation is a pattern associated with elevation of Multiple Estrogens caused by impaired clearance due to Hepatic Portal Hypertension, and/or bacterial toxins preventing clearance of hormones from the body. Another factor to consider is alteration to the Hypothalamus-Pituitary-Gonad (HPG) Axis.
- Elevation in Estrogen mimic Low Thyroid Symptoms.
- Thyroid Resistance is caused by cellular inflammation occurring throughout the body. An possibility is failure to adequately monitor Thyroid Hormone Medications.
- Cellular Inflammation and improper Thyroid Hormone Medication dosage mimics Low Thyroid Symptoms.