Chronic Fatigue is a common complaint but I don’t have to tell you that. It has been given syndrome status as Chronic Fatigue Syndrome (CFS). Somebody starts blaming the mitochondria, which has now become Mitochondrial Syndrome. Let me translate “syndrome.” It is Doctor speak for “we don’t know but lump these symptoms together and give it a name.” There is a common meme on the Internet is to blame components of the mitochondria, listing 18 different different types of Mitochondropathy.
Mitochondria are the body’s cellular power plants. Why isn’t it generating power? Just as any power generators require fuel. The “fuel” for mitochondria is glucose and oxygen. Growing up on a farm, you learn the first question to ask is – is it out of fuel. Sometimes, it is that simple. So I checked the Professional Influencers websites to find out if they were checking the fuel for mitochondria. Do a simple ‘Ctrl F’ on their sites and type in glucose or oxygen. I was surprised to see none of them are bothering to check the fuel. Most are copy and paste – posting identical information. A couple of the sites mention oxygen during description of the mitochondrial components. But not as a requirement for mitochondrial production of energy.
On the farm, you learn to check the fuel in the tractor before tearing apart the generator. If you are using solar, check where the sun is. Is it cloudy? The Professional Influencers start tearing apart the mitochondria and recommending supplements with convenient links to sales pages, much like the repair shop selling new spark plugs. New spark plugs will not work if there is no fuel. Solar is probably closest to Mitochondria energy production. Changes in blood flow, pH and metabolic function all play roles in the delivery of glucose and oxygen. Just as the sun moving across the sky changes the angle of the sun to the solar panel, clouds, and nighttime, all playing a role in how much power a solar panel will generate. Movement, blood flow and the stickiness of the Red Blood Cells (RBCs) play a role in the delivery of oxygen and glucose to the mitochondria. Insulin resistance (Pre-diabetes) makes RBCs stick together. It gets worse with Diabetes. To get the most output, everything must come together to deliver the maximum amount of fuel for both solar and mitochondria energy production.
Mitochondria rely on the blood to deliver glucose and red blood cells ability to carry and deliver oxygen. Do not assume, just because a blood vessel runs past the cells that oxygen and glucose are being delivered.
Conditions such as Insulin Resistance or Metabolic Syndrome alter both the delivery of oxygen and glucose. These are fairly simple to reverse and have fallen out of favor with the Professional and Social Media Influencers. They are not lucrative enough.
Prediabetes & Insulin Resistance
What is insulin?
Insulin is a hormone made in the pancreas, an organ located behind the stomach. The pancreas contains clusters of cells called islets. Beta cells within the islets make insulin and release it into the blood.
Insulin plays a major role in metabolism—the way the body uses digested food for energy. The digestive tract breaks down carbohydrates—sugars and starches found in many foods—into glucose. Glucose is a form of sugar that enters the bloodstream. With the help of insulin, cells throughout the body absorb glucose and use it for energy.
Insulin resistance is associated with low-grade inflammatory response. Insulin resistance is associated with an enhanced degree of Red Blood Cell (RBCs) adhesiveness/aggregation. Vascular complications are common in subjects with ‘metabolic syndrome’, insulin resistance as a result of RBCs sticking together. There is a significant correlation exists between the degree of RBC adhesiveness/aggregation and the degree of insulin resistance and that of inflammation.
Insulin resistance is associated with an accelerated formation of a blood clumping within an artery. An enhanced inflammatory response exists in individuals with the insulin-resistance syndrome, which is related to the development of atherosclerosis and positive ANA antibodies. RBC clumping is detrimental to capillary blood flow and tissue oxygenation for the mitochondria.
But Doctor, I don’t fit the picture for insulin resistance. I understand you don’t fit the exact picture for insulin resistance. You also don’t fit the exact picture for low thyroid, Lyme Disease, or whatever condition you are being treated for. But that didn’t stop them from diagnosing you and treating you for that condition.
What happens with insulin resistance?
The consequences of insulin resistance are twofold. 1) RBC sticking together impairing blood flow and delivery of oxygen and glucose. 2) impaired delivery of glucose into the cells of the body.
In insulin resistance, muscle, fat, and liver cells do not respond properly to insulin and thus cannot easily absorb glucose from the bloodstream. As a result, the insulin receptors on the cells are not responding to the presence of insulin. The body needs higher levels of insulin to help glucose enter cells. This puts added stress on the 1% (endocrine) of the pancreas responsible for producing insulin. With insulin resistance, it’s as if insulin is knocking on the door, but the cells can’t hear it. The pancreas responds by pumping out even more insulin (knocking louder) in an effort to get glucose into the cells, and this eventually causes Type 2 diabetes.
The beta cells in the pancreas try to keep up with this increased demand for insulin by producing more. As long as the beta cells are able to produce enough insulin to overcome the insulin resistance, blood glucose levels stay in the healthy range.
This is made difficult by the 99% (exocrine) of the pancreas producing digestive enzymes. Without stomach acid, enzymes are trapped in the pancreas. No – betaine HCl supplements are not the same as stomach acid. The stomach does not produce “betaine” HCl. The proper quality and quantity of stomach acid stimulates hormone release in the small intestine to signal the pancreas to release the enzymes. Trapped in the pancreas, enzymes are activated and begin digesting the unprotected insulin producing endocrine cells of the pancreas. Then quantity control of insulin suffers as the pancreas is auto-digested.
Why Doctors Miss the Initial Warning Sign of Insulin Resistance
Doctors have been trained to measure a person’s fasting blood sugar, or the glucose levels present in your blood, at least eight hours after your last meal. Most don’t express concern until results show blood sugar levels reaching 110 mg/dl “and” you have the proper body type. You can be thin and have insulin resistance. That’s when they start “watching it.” Then, once your blood sugar reaches 126 mg/dl, your doctor will diagnose you with Pre-diabetes. Thus preparing you for the meme of a life-long disease. That is if they ever consider insulin resistance when there are so many other conditions that have the same ubiquitous symptoms.
Single markers should never be used for a diagnosis, i.e. glucose – insulin resistance, TSH – Thyroid, etc.
Markers for Insulin Resistance include:
The important thing to note is that blood sugar is the last thing to increase…so for many people, a fasting glucose test detects insulin resistance too late. For some, their digestion is so poor their blood sugar is never high. I have seen so many Professional and Social Media posting with their new glucose meters and how they are checking their blood sugar throughout the day. There is usually for only one or two posts and these Toy Collectors are on the next thing.
Delivery of Glucose
Insulin resistance is accompanied by impairment in the ability of insulin to deliver glucose to the cells and in turn the mitochondria.
Red blood cell agglutination occurs as a result of insulin resistance. Blood cell agglutination results in hypoxia/hypercapnia causing mitochondrial dysfunction
Insulin Resistance/Diabetes causes blood to be hyper-viscous and increased red blood cell agglutination, which lead to severe microcirculation disturbance, osteoporosis, hyperlipemia, imparing the delivery of both oxygen and glucose.
Delivery of Oxygen
If there’s one thing that mitochondria thrive on, its oxygen. Mitochondria require oxygen and glucose to produce ATP in sufficient quantities to drive energy-requiring reactions. Oxygen carrying molecules, such as hemoglobin and myoglobin are necessary to transport oxygen to where it is needed.
In “normal” conditions, Oxygen bound to hemoglobin in the blood diffuses down a steep pressure gradient into tissues as blood travels through capillaries. Next oxygen diffuses into the mitochondria.
As blood flows through the capillaries in our metabolizing tissues, oxygen diffuses out of the red blood cells.
Areas of high turbulence in the vasculature accelerate the release of oxygen from hemoglobin. In the circulation, there is no specific barrier to oxygen diffusion in the blood vessels that prevents oxygen exit. As a consequence, oxygen continuously diffuses out of the red blood cell, in the same way that the delivery of water transported by a leaky bucket is a function of how fast the bucket is carried. Red blood cells become hypoxic (oxygen deficient) after passing through turbulence until their next pass through the lungs. Hypoxic red blood cell pass by downstream tissues and mitochondria leaving them in a hypoxic state. The farthest areas of the body – brain, hands and feet are the most prone to being hypoxic.
Hypoxia Deactivates Mitochondria
Hypoxia deactivates Mitochondria. Hypoxia causes mitochondria to deactivate going into a dormant state. Let’s get this straight. Not all Mitochondria are shut down simultaneously. That would be death. What would a 15%, 25% or 50% deactivation of Mitochondria do to your energy levels?
What Mitochondria supplement will reactivate the mitochondria being deprived of oxygen? Of course the Mitochondria are not working. They can’t without their fuel – glucose and oxygen.
Doctor can’t I jump in a hyperbaric chamber or use a oxygen concentrator? Yes. Those will increase the oxygen in the body. But not enough to restore your energy. At best, these are a temporary quick fix, somewhere on the lines of a high interest payday loan. Especially when the red blood cell agglutination caused insulin resistance has not been dealt with.
Do the math:
- Mitochondria with adequate oxygen and glucose produce 38 ATPs.
- Mitochondria with adequate glucose but lacking oxygen produce 2 ATPs.
- Mitochondria without oxygen and glucose produce Zero ATPs and deactivate going into power saver mode.
Supplements supporting the Mitochondria drive those that are still active to work harder with less glucose and oxygen. This causes them to age prematurely. Yes, Mitochondria do age and need to be replaced.
Bone Marrow Fatigue Results Production of Damaged Red Blood Cells
Inflammation is part of the healing process for wounds and infections. Inflammation is a normal immune system response that functions to protect the body from infection and diseases. During inflammation, white blood cells and other body chemicals attempt to remove any potentially harmful substances from the body.
Symptoms vary depending on the individual and the severity and time the bone marrow has been overworked. Symptoms may include:
- Tiredness, or fatigue
- Excessive bleeding
- Pinpoint red spots on the skin caused by bleeding from small blood vessels
- Easy bruising
- Frequent infections
- Pale skin
- Shortness of breath
The body is set up for short sharp bursts of inflammation, to combat microbial, mechanical or chemical insults. The whole point is to generate enough inflammation to combat the threat through (stimulatory neurotransmitters, inflammatory cytokines & chemokines, white blood cells and the sympathetic nervous system) and then cool, repair and close up the area of injury ending the inflammation through (inhibitory neurotransmitters, anti-inflammatory cytokines and chemokines, white blood cells and the parasympathetic nervous system).
Disruption of the NEI Supersystem through long-term stress and the ingestion of inappropriate foods and chemicals irritation create a state of chronic inflammation. Our immune system can become fatigued, working at a low level, no longer able to generate enough energy for full protection, but still causing on going cell damage through low-grade inflammation. We become both depleted of certain white blood cells and others continue to maintain the inflammation. Then add to the fatigue by overstimulating the immune system with immune boosting supplements. Read More …
Summarizing Chronic Fatigue and Mitochondriopathy
Symptoms of fatigue are attributed to disease conditions, e.g. thyroid, and about every other condition being diagnosed. Let’s start by checking the fuel first with Lab tests such as the Bio-Screen Sustain Max. Too many start with EBV antibodies that 90% (ninety percent) of the world’s population is positive for. Talk about low hanging fruit.
Call today if you suffer from chronic fatigue and are sick and tired of being sick and tired. 530-615-4083